| 发明名称 | Recombinant human G-CSF dimer and use thereof for the treatment of neurological diseases | ||
| 摘要 | This invention relates to a recombinant human G-CSF (rhG-CSF) dimer and its use in the treatment of neurological disorder. In particular, upon ischemic neural injury in animal, this invention can be used to protect neurons with the use of rhG-CSF dimer such that function of injured nerves can be restored. Serum half-life of G-CSF dimer of this invention is prolonged and the biological activity thereof is increased. | ||
| 申请公布号 | US9273108(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201314014413 | 申请日期 | 2013.08.30 |
| 申请人 | Generon (Shanghai) Corporation Ltd. | 发明人 | Yan Xiaoqiang;Huang Zhihua;Yang Hongzhou;Sun Bill N. C.;Huang Yuliang |
| 分类号 | C07K16/00;C07K14/535;C12N15/09;C12N15/24;A61P25/00;A61K38/19 | 主分类号 | C07K16/00 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. An isolated polypeptide comprising the amino acid sequence of any one of SEQ ID NOs:4-7. | ||
| 地址 | Shanghai CN | ||