Predictive markers for ovarian cancer

摘要

Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. Associated test kits, computer and analytical systems as well as software and diagnostic models are also provided.

主权项

1. A set of reagents to measure the levels of biomarkers in a specimen, wherein the biomarkers are selected from the group consisting of the following panels of biomarkers or measurable fragments thereof:
(a) myoglobin, CRP, FGF basic protein and CA 19-9; (b) Hepatitis C NS4, Ribosomal P Antibody and CRP; (c) CA 19-9, TGF alpha, EN-RAGE, EGF and HSP 90 alpha antibody, (d) EN-RAGE, EGF, CA 125, Fibrinogen, Apolipoprotein CIII, Cholera Toxin and CA 19-9; (e) Proteinase 3 (cANCA) antibody, Fibrinogen, CA 125, EGF, CD40, TSH, Leptin, CA 19-9 and lymphotactin; (f) CA125, EGFR, CRP, IL-18, Apolipoprotein CIII, Tenascin C and Apolipoprotein A1; (g) CA125, Beta-2 Microglobulin, CRP, Ferritin, TIMP-1, Creatine Kinase-MB and IL-8; (h) CA125, EGFR, IL-10, Haptoglobin, CRP, Insulin, TIMP-1, Ferritin, Alpha-2 Macroglobulin, Leptin, IL-8, CTGF, EN-RAGE, Lymphotactin, TNF-alpha, IGF-1, TNF RII, von Willebrand Factor and MDC; (i) CA-125, CRP, EGF-R, CA-19-9, MIP-1, IL-18 and VCAM-1; j) CA-125, CRP, EGF-R, CA-19-9, MIP-1, vWF and VCAM-1; (k) CA-125, CRP, EGF-R, CA-19-9, Serum Amyloid P, IL-6 and MIP-1; (1) CA-125, CRP, EGF-R, CA-19-9, IL-6, MIP-1 and vWF; (m) CA-125, CRP, EGF-R, CA-19-9, Serum Amyloid P, ApoCIII and IL-18; (n) CA-125, CRP, EGF-R, CA-19-9, Apo A1, MIP-1 and vWF; (o) CA-125, CRP, EGF-R, CA-19-9, Serum Amyloid P, Apo A1, and MIP-1; (p) CA-125, CRP, EGF-R, IL-6, myoglobin, MIP-1 and myeloperoxidase; (q) CA-125, CRP, EGF-R, CA-19-9, myoglobin MIP-1 and Growth Hormone; (r) CA-125, CRP, EGF-R, CA-19-9, MIP-1, Growth Hormone and myeloperoxidase; (s) CA-125, CRP, EGF-R, CA-19-9, MIP-1, Growth Hormone and IL-18; (t) CA-125, CRP, EGF-R, CA-19-9, myoglobin, Growth Hormone and VCAM-1; (u) CA-125, CRP, EGF-R, CA-19-9, myoglobin, MIP-1 and Leptin; (v) CA-125, CRP, EGF-R, CA-19-9, myoglobin, Leptin and Growth Hormone; (w) CA-125, CRP, EGF-R, CA-19-9, IL-6, myoglobin and Growth Hormone; (x) CA-125, CRP, EGF-R, CA-19-9, myoglobin, Leptin and myeloperoxidase; (y) CA-125, CRP, EGF-R, CA-19-9, myoglobin, MIP-1 and insulin; (z) CA-125, CRP, EGF-R, CA-19-9, myoglobin, MIP-1 and ferritin; (aa) CA-125, CRP, EGF-R, CA-19-9, myoglobin, MIP-1 and myeloperoxidase; (bb) CA-125, CRP, EGF-R, CA-19-9, Serum Amyloid P, myoglobin, and MIP-1; (cc) CA-125, CRP, EGF-R, CA-19-9, myoglobin, MIP-1 and haptoglobulin; (dd) CA-125, CRP, EGF-R, CA-19-9, ApoA1, myoglobin, MIP-1 and leptin; (ee) CA-125, CRP, EGF-R, CA-19-9, IL-6, vWF and ApoCIII; (ff) CA-125, CRP, EGF-R, Serum Amyloid P, IL-6, MIP-1 and ferritin; (gg) CA-125, CRP, EGF-R, CA-19-9, vWF, ApoCIII and ferritin; (hh) CA-125, CRP, EGF-R, CA-19-9, IL-6, MIP-1 and ferritin; (ii) CA-125, CRP, EGF-R, CA-19-9, MIP-1, vWF and ApoCIII; (jj) CA-125, CRP, EGF-R, CA-19-9, Serum Amyloid P, ApoCIII and ferritin; (kk) CA-125, CRP, EGF-R, CA-19-9, IL-6, CK-MB and vWF; and (ll) CA-125, CRP, EGF-R, CA-19-9, MIP-1, IL-10 and ferritin.