MIC-1 fusion proteins and uses thereof

摘要

The invention relates to MIC-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC-1 protein or an analog thereof at the C-terminus of the fusion protein and a functional variant of human serum albumin at the N-terminus of the fusion protein connected via a peptide linker. The compounds of the invention have MIC-1 activity. The invention also relates to pharmaceutical compositions comprising such compounds and pharmaceutically acceptable excipients, as well as the medical use of the compounds.

主权项

1. A fusion protein of formula (I):
A-B—C  (I), wherein A is human serum albumin or a functional variant thereof; B is a peptide linker having the amino acid sequence of SEQ ID NO:9; and C is a MIC-1 protein or an analogue thereof, wherein the C-terminus of the human serum albumin or functional variant thereof is fused to the N-terminus of the peptide linker, and wherein the C-terminus of the peptide linker is fused to the N-terminus of the MIC-1 protein or analogue thereof.