| 发明名称 | Method of inhibiting nonsense-mediated mRNA decay | ||
| 摘要 | Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased. | ||
| 申请公布号 | US9271998(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201314082346 | 申请日期 | 2013.11.18 |
| 申请人 | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 发明人 | Pe'ery Tsafi;Mathews Michael B.;Hoque Mainul;Hanauske-Abel Hartmut M. |
| 分类号 | A61K31/713;A61K31/426;A61K31/44;A61K31/4412;A61K31/4418 | 主分类号 | A61K31/713 |
| 代理机构 | Fox Rothschild LLP | 代理人 | Fox Rothschild LLP |
| 主权项 | 1. A method for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased. | ||
| 地址 | New Brunswick NJ US | ||