| 发明名称 |
Osteoinductive bone graft substitute |
| 摘要 |
An osteoinductive bone graft substitute including an osteoinductive calcium phosphate component retained within a collagen scaffold, wherein the collagen scaffold is formulated to maintain the osteoinductivity of the calcium phosphate component while also exhibiting the following characteristics (1) ability to absorb bone marrow and/or other physiologic liquids, (2) compression resistance; (3) moldability; (4) retaining the calcium phosphate component during and after manipulation of the collagen scaffold and (5) fibrous collagen matrix that retains but does not occlude the osteoinductive calcium phosphate component. |
| 申请公布号 |
US9272072(B1) |
申请公布日期 |
2016.03.01 |
| 申请号 |
US201514697443 |
申请日期 |
2015.04.27 |
| 申请人 |
NuVasive, Inc. |
发明人 |
Ismailoglu Ali;Vizesi Frank;Chen Sung-Ching;Lai Po-Hung;Chien Kehsin |
| 分类号 |
A61L27/46;A61L27/54 |
主分类号 |
A61L27/46 |
| 代理机构 |
|
代理人 |
Spangler Jonathan;Russell Jennifer |
| 主权项 |
1. A method of making an osteoinductive bone graft substitute, comprising:
mixing a first soluble collagen solution having a first concentration with osteoinductive calcium phosphate granules to create a slurry; blending the slurry with a second soluble collagen solution having a second concentration which is greater than the first concentration to create a mixture having a final collagen concentration of 65 mg/g; pouring the mixture into a mold; and lyophilizing the mixture. |
| 地址 |
San Diego CA US |
