发明名称 |
Azabicyclo compound and salt thereof |
摘要 |
It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein X1 represents CH or N; any one of X2, X3 and X4 represents N, and the others represent CH; any one or two of Y1, Y2, Y3 and Y4 represent C—R4, and the others are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; R2 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R3 and R4 represent —CO—R5 or the like. |
申请公布号 |
US9273045(B2) |
申请公布日期 |
2016.03.01 |
申请号 |
US201414242063 |
申请日期 |
2014.04.01 |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
Kitade Makoto;Ohkubo Shuichi;Yoshimura Chihoko;Yamashita Satoshi;Oshiumi Hiromi;Uno Takao;Kawai Yuichi |
分类号 |
C07D471/04;C07D209/08;C07D519/00 |
主分类号 |
C07D471/04 |
代理机构 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
代理人 |
Oblon, McClelland, Maier & Neustadt, L.L.P. |
主权项 |
1. A method for treating cancer, the method comprising:
administering an effective amount of 3-Ethyl-4-{3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl}benzamide or a salt thereof to a patient in need thereof. |
地址 |
Tokyo JP |