Method for determining depression, kit for analyzing serotonin transporter, and kit for analyzing ubiquitinated serotonin transporter in blood

摘要

[Problem] To provide: a method for utilizing a novel marker, including a method for determining depression; and a kit for analyzing an ubiquitinated serotonin transporter.;[Solution] A method for determining depression, comprising a step of analyzing the proportion of an ubiquitinated serotonin transporter in a blood sample collected from a subject; and a kit for analyzing an ubiquitinated serotonin transporter in blood, which comprises an ubiquitinated protein collector material and an anti-serotonin transporter antibody and is used for the analysis of the proportion of an ubiquitinated serotonin transporter in a collected blood sample.

主权项

1. A method for determining depression,
wherein an amount of a serotonin transporter including an amount of an ubiquitinated serotonin transporter in a blood sample treated with a proteasome inhibitor is defined as an amount of an inhibitor-treated serotonin transporter, and an amount of a serotonin transporter in an untreated blood sample is defined as an amount of an untreated serotonin transporter, the method comprising: a step of analyzing the amount of the inhibitor-treated serotonin transporter and the amount of the untreated serotonin transporter in a blood sample collected from a subject; a step of comparing the difference between the amount of the untreated serotonin transporter and the amount of the inhibitor-treated serotonin transporter obtained from the blood sample collected from the subject (the difference between the untreated and inhibitor-treated amounts), and the difference between the untreated and inhibitor-treated amounts obtained from blood sampling of one or more healthy subjects; and a step of determining that the subject has depression when the difference between the untreated and inhibitor-treated amounts obtained from the blood sample collected from the subject is smaller than the difference between the untreated and inhibitor-treated amounts obtained from the blood sampling of the one or more healthy subjects.