Activation of bone and cartilage formation

摘要

Provided is a method of activating osteogenic or chondrogenic activity at a site in a subject in need thereof. Also provided is a method of treating a bone or cartilage defect in a subject. Additionally, the use of a reduced pressure apparatus for treating a bone or cartilage defect adjacent to dura mater, periosteum, or endosteum is provided. Further provided is a composition for treating a bone or cartilage defect. Also, the use of a reduced pressure apparatus and a biocompatible scaffold for the manufacture of a composition for treating a bone or cartilage defect adjacent to dura mater, periosteum or endosteum is provided.

主权项

1. A system for activating osteogenic or chondrogenic activity at a tissue site in a subject, the system comprising:
a source of reduced pressure; and a manifold formed from an open-cell reticulated foam having pore sizes between about 400 microns and about 600 microns and adapted to be fluidly connected to the source and positioned adjacent dura mater for applying reduced pressure to the dura mater of the subject adjacent the tissue site in the subject.