| 发明名称 | Intra-operative molecular imaging | ||
| 摘要 | A system for detecting tumor margins includes a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, an applicator for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell. | ||
| 申请公布号 | US9271653(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201314014889 | 申请日期 | 2013.08.30 |
| 申请人 | Case Western Reserve University | 发明人 | Basilion James |
| 分类号 | A61B5/00;A61B19/00;A61N5/10;A61B18/20 | 主分类号 | A61B5/00 |
| 代理机构 | Tarolli, Sundheim, Covell & Tummino LLP | 代理人 | Tarolli, Sundheim, Covell & Tummino LLP |
| 主权项 | 1. A system for detecting cancer margins, comprising: a topical protease-specific, fluorescence imaging probe that is activatable by enzymatic activation to produce a visually differentiated signal upon topical application to a targeted cancer cell that secretes an enzyme that activates the protease-specific, fluorescence imaging probe, the probe being selected from the group consisting of GB119 and BMV084; means for topically administering the imaging probe to the cancer cell; and an imaging device to detect activation of the imaging probe administered to the cancer cell. | ||
| 地址 | Cleveland OH US | ||