Methods for microbial biofilm destruction

摘要

Compositions and methods for the dissolution of a microbial biofilm are provided, where the method comprises contacting a microbiofilm with an effective dose of a curcumin derivative as a biofilm inhibitor. In some embodiments the curcumin derivative is dimethoxycurcumin. In some embodiments the biofilm comprises E. coli, e.g. including uropathogenic E. coli. The biofilm can be present in vitro or in vivo. The biofilm inhibitor may be administered alone, or in combination with bacteriocidal agents.

主权项

1. A method of inhibiting microbial biofilm maintenance or formation, the method consisting of:
contacting microbes involved in said biofilm formation or maintenance with an effective dose of dimethoxycurcumin (1, 7-bis(3, 4-dimethoxyphenyl)-1, 6-heptadiene-3, 5-dione), wherein the effective dose provides for a concentration at the biofilm site of from about 0.01 μM to about 10 mM.