Surgical fasteners and methods for sealing wounds

摘要

A method for closing a wound in tissue is provided which includes providing a surgical fastener having a plurality of reactive members of a specific binding pair attached on a surface of the surgical fastener, and providing tissue with a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members on the surface of the surgical fastener with the complimentary reactive members on the tissue, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the device to the tissue.

主权项

1. A method comprising:
wetting tissue with a liquid precursor having a plurality of reactive members of a specific binding pair, the reactive members conjugated to a linker, wherein the reactive members are attached to components of the tissue via the linker, and the linker is degradable by hydrolysis or enzymatic action; and contacting the tissue with a surgical fastener having a functionalized surface including a plurality of complementary reactive members of the specific binding pair, wherein upon contact of the reactive members attached to the tissue via the linker, with the complimentary reactive members on the surgical fastener, covalent bonds are formed between the reactive members and the complementary reactive members, thus adhering the surgical fastener to the tissue.