Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles

摘要

The present disclosure provides functionalized magnetic nanoparticles (MNPs) comprising a functional group that binds to β-amyloid deposits and/or neurofibrillary tangles. The present disclosure provides compositions comprising the functionalized MNPs, and methods of using the functionalized MNPs in imaging β-amyloid deposits and neurofibrillary tangles.

主权项

1. A pharmaceutical composition comprising:
a) a functionalized magnetic nanoparticle (MNP) comprising a magnetic core and a functional group that binds aggregated β-amyloid protein and/or neurofibrillary tangles, wherein said functional group is coupled via an epoxy group to the magnetic core, wherein said functionalized magnetic nanoparticle is capable, when introduced into the bloodstream of a mammalian subject, of crossing the blood-brain barrier of a mammalian subject, and wherein the functional group is 2-(1-{6-[(2-hydroxyethyl)(methy)amino]-2-naphthyl}lethylidene)malononitrile(HODDNP), or a derivative or analog thereof; and b) a pharmaceutically acceptable carrier.