| 发明名称 | IFN-beta compositions, preparation methods and uses thereof | ||
| 摘要 | The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time. | ||
| 申请公布号 | US9272020(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201214118757 | 申请日期 | 2012.05.16 |
| 申请人 | ARES TRADING S.A. | 发明人 | Leblanc Daniel;Lamme Evert Nicolaas;Baldascini Helen Gabriela;Richard Joel;Checot Frederic;Chan You-Ping;Kravtzoff Roger;Pouliquen Gauthier |
| 分类号 | A61K38/21;A61K9/00;A61K47/34;A61K47/36;A61K9/20;A61K9/19;A61K47/42 | 主分类号 | A61K38/21 |
| 代理机构 | Saliwanchik, Lloyd & Eisenschenk | 代理人 | Saliwanchik, Lloyd & Eisenschenk |
| 主权项 | 1. A solid pharmaceutical composition comprising: interferon-beta (IFN-beta); a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, wherein the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta is between 24 and 125: and a sucrose in a sucrose/IFN-beta weight/weight ratio between 100 and 600. | ||
| 地址 | Aubonne CH | ||