| 主权项 |
1. A method for treating contrast agent-induced nephropathy in a subject comprising administering a therapeutically effective amount of an activated fatty acid, a prodrug, or a metabolite thereof, wherein the activated fatty acid is an unsaturated or polyunsaturated fatty acid having an aliphatic chain comprised of 4 to 25 carbons and one or more electron withdrawing groups associated with at least one carbon-carbon double bond, the one or more electron withdrawing groups being selected from the group consisting of aldehyde (—COH), acyl (—COR), carbonyl (—CO), carboxylic acid (—COOR), ester (—COOR), halides (—Cl, —F, —Br, —I), fluoromethyl (—CFn, n=I-3), allyl fluoride (—CH═CHCH2F), cyano (—CN), sulfoxide (—SOR), sulfonyl (—S02R), sulfonic acid (—S03H), 1°, 2° and 3° ammonium (—NR3 +), or nitro (—N02), wherein R is a hydrogen, methyl or C2-C6 alkyl, further comprising administering one or more secondary agents selected from the group consisting of cytoprotective agents, angiotensin II inhibitors, angiotensin converting enzyme (ACE) inhibitors, and combinations thereof. |
