Systems and devices for selective cell lysis and methods of using same

摘要

A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and at least one pressure sensor for measuring tissue apposition pressure, the pressure sensor being mounted on one of the housing and the needle array.

主权项

1. A system for the generation and delivery of microbubbles, comprising:
a liquid reservoir configured to contain a fluid; a gas reservoir configured to contain a gas or vapor; a bubble generator,
wherein the bubble generator is in fluidic communication with the liquid reservoir and the gas reservoir,wherein the bubble generator is configured to receive liquid from the liquid reservoir and gas from the gas reservoir and combine the received liquid and gas to create a solution comprising microbubbles; a fluid injection device,
wherein the fluid injection device comprises a needle array comprising one or more needles; andwherein the fluid injection device is in fluidic communication with the bubble generator and is configured to receive the solution comprising microbubbles and to inject the solution comprising microbubbles into a region of target tissue.