| 发明名称 | Methods and systems for modulating hormones and related methods, agents and compositions | ||
| 摘要 | Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual. | ||
| 申请公布号 | US9272051(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201414320159 | 申请日期 | 2014.06.30 |
| 申请人 | California Institute of Technology;The Regents of the University of California;The United States Government Represented by the Department of Veterans Affairs | 发明人 | Goddard, III William A.;Menna Mark;Pandol Stephen;Abrol Ravinder |
| 分类号 | A61K31/513;A61K31/704;A61K31/352;A61K31/122;A61K31/12;A61K31/353;A61K47/48;A61K31/10;A61K31/167;A61K31/205;A61K31/365;A61K31/4375;A61K31/4745;A61K31/7016;G01N33/566;A61K31/17 | 主分类号 | A61K31/513 |
| 代理机构 | The Law Offices of Leslie B. Overman | 代理人 | The Law Offices of Leslie B. Overman |
| 主权项 | 1. A composition comprising a combination of 6-n-propylthiouracil and a complementary molecule, wherein the complementary molecule interferes with systemic absorption and release of 6-n-propylthiouracil upon enteral administration, wherein the complementary molecule is polyethylene glycol, wherein the polyethylene glycol is conjugated to the 6-n-propylthiouracil, and wherein the combination results in prolonged activation of bitter taste receptors in the gut. | ||
| 地址 | Pasadena CA US | ||