Increased T-cell tumor infiltration and eradication of metastases by mutant light

摘要

Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.

主权项

1. A human recombinant mutant LIGHT protein comprising the amino acid sequence of SEQ ID NO: 16, wherein the mutant LIGHT protein does not comprise the proteolytic site EQLI (SEQ ID NO: 17) located at positions 81-84 of the native human LIGHT protein sequence of SEQ ID NO: 15 and is resistant to protease digestion, and wherein the protein can be expressed on the surface of cells such that the protein functions to, reduce metastasis.