发明名称 |
Ketoprofen-containing aqueous adhesive skin patch |
摘要 |
Provided is a water-based patch that contains ketoprofen as an active ingredient, provides high transdermal absorbability of the ketoprofen, and has high safety and high storage stability. The water-based patch contains the ketoprofen, an amine, and polyethylene glycol. In the water-based patch, the added amount of the ketoprofen in a paste is 0.1 to 5% by weight, the added amount of the amine in the paste is 0.5 to 10% by weight, and the added amount of the polyethylene glycol in the paste is 5 to 30% by weight. Particularly, in the water-based patch, diisopropanolamine is used as the amine. |
申请公布号 |
US9271944(B2) |
申请公布日期 |
2016.03.01 |
申请号 |
US201113583940 |
申请日期 |
2011.03.11 |
申请人 |
Teikoku Seiyaku Co., Ltd. |
发明人 |
Tani Kazuha |
分类号 |
A61K9/70;A61K31/192;A61K47/10 |
主分类号 |
A61K9/70 |
代理机构 |
Crowell & Moring LLP |
代理人 |
Crowell & Moring LLP |
主权项 |
1. A water-based patch comprising an adhesive paste comprising
a ketoprofen, an amine as a solubilizing agent for the ketoprofen, polyethylene glycol as an esterification inhibitor for the ketoprofen, cross-linking agent, and polyacrylic acid and/or salt thereof, wherein the amount of ketoprofen in the adhesive paste is 0.1 to 5% by weight, the amount of the amine in the adhesive paste is 0.5 to 10% by weight, the amount of the polyethylene glycol in the adhesive paste is 5 to 30% by weight, the amount of the cross-linking agent in the adhesive paste is 0.01 to 5% by weight, and the amount of polyacrylic acid and/or salt thereof in the adhesive paste is 1 to 30% by weight, wherein the adhesive paste is prepared by the steps of: (1) solubilizing the ketoprofen in the amine to form a solubilized ketoprofen, (2) preparing a hydrated gel comprising the polyethylene glycol, cross-linking agent and polyacrylic acid and/or salt thereof in water, and (3) mixing the solubilized ketoprofen into the hydrated gel uniformly to generate a paste. |
地址 |
Higashikagawa-shi JP |