| 发明名称 | Methods, systems and computer program products for non-invasive determination of blood flow distribution using speckle imaging techniques and hemodynamic modeling | ||
| 摘要 | A non-invasive method for measuring blood flow in principal vessels of a heart of a subject is provided. The method includes illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow rate in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image. | ||
| 申请公布号 | US9271658(B2) | 申请公布日期 | 2016.03.01 |
| 申请号 | US201213819817 | 申请日期 | 2012.01.09 |
| 申请人 | East Carolina University | 发明人 | Ferguson, Jr. Thomas Bruce;Hu Xin-Hua;Chen Cheng |
| 分类号 | G06K9/00;A61B5/026;A61B5/00;A61B5/02;G02B27/48;G06T7/00 | 主分类号 | G06K9/00 |
| 代理机构 | Myers Bigel Sibley & Sajovec | 代理人 | Myers Bigel Sibley & Sajovec |
| 主权项 | 1. A non-invasive method for measuring blood flow distribution in principal vessels of a heart of a subject, the method comprising: passively illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm and a field of view including the region of interest is at least about 2 square centimeters; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject and the acquisition being triggered by the motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow speed in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image. | ||
| 地址 | Greenville NC US | ||