发明名称 |
GENE TRANSFER INTO AIRWAY EPITHELIAL STEM CELL BY USING LENTIVIRAL VECTOR PSEUDOTYPED WITH RNA VIRUS SPIKE PROTEIN |
摘要 |
The present inventors successfully introduced genes into stem cells of airway epithelial tissues using simian immunodeficiency virus vectors pseudotyped with F and HN, which are envelope glycoproteins of Sendai virus. Gene transfer into airway epithelial tissue stem cells using a vector of the present invention is useful for gene therapy of genetic respiratory diseases such as cystic fibrosis. Furthermore, it is possible to select respiratory organs such as the lungs as production tissues for providing proteins that are deficient due to genetic diseases. |
申请公布号 |
PT1950307(E) |
申请公布日期 |
2016.02.29 |
申请号 |
PT20060822478T |
申请日期 |
2006.10.27 |
申请人 |
IP PHARMA CO., LTD. |
发明人 |
null, null;null, null;null, null;null, null;null, null;null, null |
分类号 |
C12N15/867;A61K35/76;A61K38/00;A61K38/17;A61K48/00;A61P11/00;C07K14/47;C12N5/10;C12N15/86 |
主分类号 |
C12N15/867 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|