MORPHOLINOPURINE DERIVATIVES

摘要

THERE IS PROVIDED A NOVEL COMPOUND THAT INHIBITS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) AND/OR THE MAMMALIAN TARGET OF RAPAMYCIN (MTOR) AND EXHIBITS ANTI-TUMOR ACTIVITY. THE PRESENT INVENTION PROVIDES A COMPOUND REPRESENTED BY THE FOLLOWING FORMULA (1) HAVING VARIOUS SUBSTITUENTS THAT INHIBITS PI3K AND/OR MTOR AND EXHIBITS ANTI-TUMOR ACTIVITY: WHEREIN R¹, R², R³, R?, Ra, Rb, Rc, AND X EACH HAVE THE SAME MEANINGS AS DEFINED IN THE SPECIFICATION.