| 摘要 |
Provided are fluoromethyl-5,6-dihydro-4H-[1,3]oxazine compounds of the general formula I, wherein the variables are as defined in the specification. Examples of the compounds include N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide and N-(3-((4S,6S)-2-Amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-2-(fluoromethyl)oxazole-4-carboxamide. The compounds are inhibitors of BACE1. The compounds may be useful in the treatment of Alzheimer’s disease. |
