| 发明名称 |
ANTI-HUMAN TROP-2 ANTIBODY HAVING ANTI-TUMOR ACTIVITY IN VIVO |
| 摘要 |
The present invention provides: an antibody, which specifically reacts with hTROP-2 and has anti-tumor activity in vivo; a hybridoma, which produces the aforementioned antibody; a complex of the aforementioned antibody and a drug; a pharmaceutical composition for diagnosing or treating a tumor; a method for detecting a tumor; and a kit for detecting or diagnosing a tumor. |
| 申请公布号 |
US2016053018(A1) |
申请公布日期 |
2016.02.25 |
| 申请号 |
US201514729953 |
申请日期 |
2015.06.03 |
| 申请人 |
LIVTECH, INC. |
发明人 |
NAKAMURA Koji;OKAMURA Kentaro;TAMURA Maki;YANAI Hiroyuki;KANKE Toru |
| 分类号 |
C07K16/30;A61K47/48 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An antibody against human TROP-2, which has anti-tumor activity in vivo, wherein the amino acid sequences of CDR 1 to 3 of the H chain V region of the antibody are shown in SEQ ID NOS: 36 to 38, respectively, and/or the amino acid sequences of CDR 1 to 3 of the L chain V region of the antibody are shown in SEQ ID NOS: 41 to 43, respectively. |
| 地址 |
Kanagawa JP |
