NOVEL HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME (AS AMENDED)

摘要

The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.;A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compound of the formula (I):;;wherein

ring A is substituted or unsubstituted 5 to 7-membered cycloalkane, substituted or unsubstituted 5 to 7-membered cycloalkene or the like;

C is a carbon atom;

—X— is —N(R16)— or the like;

R16 is hydrogen, substituted or unsubstituted alkyl or the like;

R7 is substituted or unsubstituted 5- or 6-membered heteroaryl, substituted or unsubstituted 6 to 10 membered aryl;

Q1 and Q2 are each independently a carbon atom or a nitrogen atom;

-L- is —O—, —S— or the like;

R6 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or the like;

R2 is hydrogen, hydroxy or the like,

or its pharmaceutically acceptable salt or a solvate thereof.