Methods, Systems, and Devices Relating to Open Microfluidic Channels

摘要

The various embodiments described herein relate to fabricating and using open microfluidic networks according to methods, systems, and devices that can be used in applications ranging from home-testing, diagnosis, and research laboratories. Open microfluidic networks allow the input, handling, and extraction of fluids or components of the fluid into or out of the open microfluidic network. Fluids can be inserted into an open microfluidic channel by using open sections of the open microfluidic network. Passive valves can be created in the microfluidic network, allowing the creation of logic circuits and conditional flow and volume valves. The fluid can be presented via the microfluidic network to diagnostic and analysis components. Fluids and components of the fluid can be extracted from the open microfluidic network via functional open sections that are easily interfaced with other microfluidic networks or common laboratory tools.

主权项

1. A fluid collection device for use with a patient comprising:
a. a body comprising a proximal body end, a distal body end and a lumen, wherein the distal body end is configured to be placed on the skin of the patient; and b. a fluidic network comprising a first open channel disposed within the lumen, wherein the first open channel is configured to be capable of spontaneous capillary flow and at least one portion of the first open channel comprises a cross-section, the cross-section comprising:
i. at least one wetted surface;ii. a wetted perimeter comprising a length;iii. a contact angle; andiv. at least one free surface comprising an open air-liquid; andv. a free perimeter length,wherein the ratio of the free perimeter length to the wetted perimeter length is less than the cosine of the contact angle.