COMPOSITIONS AND METHODS FOR CANCER DETECTION AND TREATMENT

摘要

Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically effective amount of at least one PRMT5 inhibitor. In some embodiments pharmaceutical compositions further comprising at least one HDAC inhibitor are contemplated. Methods of treating disorders in a mammal by inhibiting PRMT5 by administering to a mammal, a therapeutically effective amount of a PRMT5 inhibitor are also disclosed.

主权项

1. A compound of formula (I)wherein
R1 is R2 is A1, A2, A3, and A4 are each individually hydrogen, halo, alkyl, alkoxyl, —OH, —NH2, or —NO2; A8, A9, A10, A11, A12, A13, and A14 are each individual hydrogen and A15 is C1-C6 alkyl; ora salt thereof.