| 摘要 |
In one aspect, the invention provides methods of inhibiting the effects of MASP-2 dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to Inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (Clq -dependent) pathway component of the immune system Intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier. |
