MULTIPOTENT POSTNATAL STEM CELLS FROM HUMAN PERIODONTAL LIGAMENT AND USES THEREOF

摘要

The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation.

主权项

1. A method for treating trauma in a subject, comprising
administering to the subject an effective amount of a composition comprising an effective amount of an isolated clonal population of periodontal ligament multipotent mammalian stem cells wherein the clonal population consists of human multipotent stem cells that proliferate, express STRO-1 and MUC 18, form colonies in vitro, and differentiate into periodontal ligament cells that produce collagen fibers and cementum in vivo, wherein the periodontal ligament multipotent stem cells were expanded ex vivo, thereby treating the trauma in the subject.