BLOCKING CD38 USING ANTI-CD38 ANTIBODY CONJUGATED TO PROTEIN G TO PROTECT NK CELLS
摘要
Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 antibody-protein G complex and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 antibody-protein G complex and 2) an anti-CD38 antibody, in either order or simultaneously.
申请公布号
WO2015195555(A8)
申请公布日期
2016.02.25
申请号
WO2015US35831
申请日期
2015.06.15
申请人
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
CHILDS, RICHARD, W.;CALDERON, LUIS, ESPINOZA;BERG, MARIA