发明名称 |
GENOSPECIFIC RADIOSENSITIZATION |
摘要 |
A method of treating a subject who has been diagnosed with cancer is described. The method includes characterizing the radiation-susceptibility of the subject by detecting a mutation in an NRF2 pathway protein in suitable sample obtained from the subject and treating the subject with radiation therapy if the subject is characterized as being radiation-susceptible, or treating the subject with radiation therapy and a radiosensitizing agent if the subject is characterized as being radioresistant. A method of determining if a subject has a history of tobacco smoking is also described that includes analyzing an NRF2 pathway protein to determine if a mutation is present in suitable sample obtained from the subject and characterizing the subject as having a history of tobacco smoking if a genetic fingerprint consistent with tobacco exposure is identified. |
申请公布号 |
US2016053323(A1) |
申请公布日期 |
2016.02.25 |
申请号 |
US201514832159 |
申请日期 |
2015.08.21 |
申请人 |
THE CLEVELAND CLINIC FOUNDATION |
发明人 |
Abazeed Mohamed |
分类号 |
C12Q1/68;A61K41/00;G01N33/68;A61K31/7088 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
|
主权项 |
1. A method of treating a subject who has been diagnosed with cancer, the method comprising:
(a) characterizing the radiation-susceptibility of the subject by detecting a mutation in an NRF2 pathway protein in suitable sample obtained from the subject; and (b) treating the subject with radiation therapy if the subject is characterized as being radiation-susceptible, or treating the subject with radiation therapy and a radiosensitizing agent if the subject is characterized as being radioresistant. |
地址 |
Cleveland OH US |