BLOCKING CD38 USING ANTI-CD38 F(AB')2 TO PROTECT NK CELLS

摘要

Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 F(ab')2 fragment and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 F(ab')2 fragment and 2) an anti- CD38 antibody, in either order or simultaneously.