发明名称 |
METHOD AND KIT FOR ASSESSMENT OF SODIUM CHANNEL-RELATED ANTI- OR PRO-ARRHYTHMIC POTENTIAL OF COMPOUNDS |
摘要 |
The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro- arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). |
申请公布号 |
WO2016026732(A1) |
申请公布日期 |
2016.02.25 |
申请号 |
WO2015EP68433 |
申请日期 |
2015.08.11 |
申请人 |
RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG |
发明人 |
KOENEN, MICHAEL;YAMPOLSKY, PESSAH;SCHWEIZER, PATRICK A.;THOMAS, DIERK;KATUS, HUGO A. |
分类号 |
G01N33/50 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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