INJECTABLE AND IMPLANTABLE CARRIER SYSTEMS BASED ON MODIFIED POLY(DICARBOXYLIC ACID POLYOL ESTERS) FOR THE CONTROLLED RELEASE OF ACTIVE INGREDIENT

摘要

The problem addressed by the invention was to show an alternative to the previously clinically used biodegradable polymers based on monomers having a hydroxycarboxylic acid structure. This problem was solved according to the invention by means of linear polyesters that are produced by esterifying dicarboxylic acids and multivalent alcohols (diols, trioles, or higher-valency alcohols) (figure 1). It was found that modified poly(dicarboxylic acid multiol esters) without further additives are suitable as injectable implants. The polymers can be directly injected without using an organic solvent. Furthermore, it was found that modified poly(dicarboxylic acid multiol esters) can be mixed with and injected with suitable biocompatible organic solvents or preformed as an implant. The carrier systems are used for the controlled release of active ingredient in human and veterinary medicine.