| 发明名称 |
TRANSDERMAL DELIVERY SYSTEM COMPRISING DONEPEZIL OR ITS SALT |
| 摘要 |
Provided is a transdermal delivery system consisting of a backing layer, a drug-containing matrix layer, and a release layer, wherein the drug-containing matrix layer includes (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a mixture of high molecular weight polyisobutylene having a weight-average molecular weight ranging from 400,000 to 3,000,000 and low molecular weight polyisobutylene having a weight-average molecular weight ranging from 25,000 to 300,000 as an adhesive, and (c) a permeation enhancer in not more than 3% by weight based on the total weight of the drug-containing matrix layer. |
| 申请公布号 |
US2016051486(A1) |
申请公布日期 |
2016.02.25 |
| 申请号 |
US201514779649 |
申请日期 |
2015.01.12 |
| 申请人 |
DAEWOONG PHARMACEUTICAL CO., LTD. |
发明人 |
CHOI Yo-Han;CHANG Hee-Chul |
| 分类号 |
A61K9/70;A61K31/445 |
主分类号 |
A61K9/70 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A transdermal delivery system consisting of a backing layer, a drug-containing matrix layer, and a release layer, wherein the drug-containing matrix layer comprises (a) donepezil or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a mixture of high molecular weight polyisobutylene having a weight-average molecular weight ranging from 400,000 to 3,000,000 and low molecular weight polyisobutylene having a weight-average molecular weight ranging from 25,000 to 300,000 as an adhesive, and (c) a permeation enhancer in not more than 3% by weight based on the total weight of the drug-containing matrix layer. |
| 地址 |
Gyeonggi-do KR |
