TARGETED LIPOSOMES ENCAPSULATING IRON COMPLEXES AND THEIR USES

摘要

The present disclosure provides liposomes comprising a lipid membrane enclosing an intraliposomal compartment, said liposome: (i) encapsulates in the intraliposomal compartment an iron complex comprising an iron moiety and a macromolecule; and (ii) has associated to its membrane a targeting moiety, the targeting moiety being exposed at the liposome's outer surface. The liposomes exhibit an immunomdulatory effect or anti-cancer effect depending on the molar ratio between the lipids forming the lipid membrane and the iron complex. As such, the liposomes can be used to treat types of inflammation, particularly inflammations that are not associated or caused by infection or be used to treat cancer. Also disclosed herein are compositions comprising the disclosed liposomes, methods of using and kits comprising the liposomes.