| 主权项 |
1. A compound having a structure represented by a formula: wherein Ar1 is a bicyclic fused ring system comprising an aryl ring fused to a 5-, 6-, or 7-membered heterocycloalkyl;
wherein the aryl ring is selected from phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, and triazinyl;wherein the aryl ring is substituted with 0, 1, 2, or 3 groups independently selected from halogen, —OH, —CN, —NH2, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkylamino, and C1-C6 dialkylamino;wherein the heterocycloalkyl is substituted with 0, 1, 2, 3, 4, or 5 groups independently selected from halogen, —OH, —CN, —NH2, oxo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 monohaloalkyl, C1-C6 polyhaloalkyl, C1-C6 alkylamino, C1-C6 dialkylamino, C1-C6 aminoalkyl, C1-C6 hydroxyalkyl, —(C=0)OR5, and —(C═O)NR6aR6b;wherein each R5 is independently selected from hydrogen, C1-C8 alkyl, and a hydroxyl protecting group;wherein each of R6a and R6b is independently selected from hydrogen, C1-C4 alkyl, and an amine protecting group; wherein R2 is selected from hydrogen, C1-C4 alkyl, and an amine protecting group; wherein R3 is selected from hydrogen and a hydroxyl protecting group; and wherein R4 is selected from hydrogen, C1-C8 alkyl, and a hydroxyl protecting group, or wherein R3 and R4 together comprise a divalent moiety having a structure represented by a formula: wherein each of R7a, R7b, R7c, and R7d is independently selected from methyl, ethyl, propyl, and butyl; or stereoisomer, a pharmaceutically acceptable salt, solvate, or polymorph thereof. |
