OPHTHALMIC COMPOSITIONS WITH OMEGA-3 FATTY ACIDS

摘要

A suspension comprising a mixture of omega-3 fatty acids suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, G′>G″ and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 mL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G″>G′ and the tear mixture has a yield value of less than 0.1 Pa.

主权项

1. A suspension comprising a mixture of omega-3 fatty acids suspended in a formulation vehicle, the vehicle comprising a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1,
wherein the suspension has the following rheological properties, G′>G″ and a suspension yield value of greater than 1 Pa, and upon addition of 30 mL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid to provide a tear mixture of the suspension in a simulated ocular condition, the tear mixture has G″>G′ and a tear mixture yield value of less than 0.1 Pa.