ANTIBODIES THAT BIND TO TL1A AND METHODS OF TREATING INFLAMMATORY OR AUTOIMMUNE DISEASE COMPRISING ADMINISTERING SUCH ANTIBODIES

摘要

Methods and compositions for treating inflammatory or autoimmune diseases in a subject comprising blocking the interaction between DR3 and TL1A. In the methods of treating inflammatory or autoimmune disease, the inflammatory or autoimmune disease can be an autoimmune disease with a T cell component, including asthma, multiple sclerosis, rheumatoid arthritis, type 1 diabetes, graft versus host disease or inflammatory bowel disease.

主权项

1. A monoclonal antibody or antigen-binding fragment thereof that specifically binds to TL1A, wherein the antibody or fragment comprises an immunoglobulin heavy chain variable region amino acid sequence comprising the complementarity determining region (CDR) sequences SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40 and an immunoglobulin light chain variable region amino acid sequence comprising the CDR sequences SEQ ID NO:44, SEQ ID NO:46 and SEQ ID NO:48.