COMPOSITIONS AND METHODS FOR TREATING HIF-1a OVER-EXPRESSING CANCERS

摘要

Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90α or VKHFSVEGQ in Hsp90α.

主权项

1. A method for treating or preventing metastasis of HIF-1α-overexpressing cancer in a subject in need thereof comprising:
a. providing a composition comprising an inhibitor of Hsp90α; and b. administering a therapeutically effective amount of the composition to the subject so as to treat HIF-1-positive cancer in the subject, so as to treat or prevent metastasis of HIF-1α-overexpressing cancer.