ANTI-SERUM ALBUMIN BINDING VARIANTS

摘要

The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domains, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.

主权项

1. A nucleic acid comprising a nucleotide sequence encoding an anti-serum albumin (SA) immunoglobulin single variable domain variant of DOM7h-11-15 (SEQ ID NO: 1), wherein the variant comprises an amino acid substitution in at least one position selected from the group consisting of: Leu49, Ala50, and Phe51,
wherein position Met32 is changed to Leu, Phe, or Ile, position Leu49 is changed to Ile, Val, or Met, position Ala50 is changed to Val, Leu, or Ile, and/or position Phe51 is changed to Leu, Val, Ile, Ala, or Tyr.