| 发明名称 |
METHOD FOR MANUFACTURING NEURAMINIC ACID DERIVATIVES |
| 摘要 |
A method for manufacturing a compound represented by the following formula (I):;;wherein R1 represents a C1-C19 alkyl, R2 represents a C1-C4 alkyl, and Ac represents an acetyl, wherein the compound of the formula (I) is optionally contained with up to 10 wt. % of a compound represented by the following formula (II):;;or a pharmacologically acceptable salt thereof, involving reacting a compound represented by the following formula (13):;;wherein R2 represents a C1-C4 alkyl and Ac represents an acetyl, with a compound represented by the formula R1C(OR7)3, wherein R1 represents a C1-C19 alkyl and R7 represents a C1-C6 alkyl, or a pharmacologically acceptable salt thereof. |
| 申请公布号 |
US2016052906(A1) |
申请公布日期 |
2016.02.25 |
| 申请号 |
US201514848787 |
申请日期 |
2015.09.09 |
| 申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
NAKAMURA Yoshitaka;MURAKAMI Masayuki;YAMAOKA Makoto;WAKAYAMA Masakazu;UMEO Kazuhiro |
| 分类号 |
C07D309/28 |
主分类号 |
C07D309/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for manufacturing a compound represented by the following formula (I):wherein R1 represents a C1-C19 alkyl group, R2 represents a C1-C4 alkyl group, and Ac represents an acetyl group, wherein the compound represented by the formula (I) is optionally contained with up to 10 wt. % of a compound represented by the following formula (II):wherein R1, R2 and Ac have the same meanings as in the formula (I), or a pharmacologically acceptable salt thereof, the method comprising:
reacting a compound represented by the following formula (13):wherein R2 represents a C1-C4 alkyl group and Ac represents an acetyl group, with a compound represented by the formula R1C(OR7)3, wherein R1 represents a C1-C19 alkyl group and R7 represents a C1-C6 alkyl group, or a pharmacologically acceptable salt thereof. |
| 地址 |
Tokyo JP |
