MECHANICAL ALTERATIONS OF BILE CANALICULI ACTIVITY AND RHO- KINASE - MYOSIN II PATHWAY AND JUNCTIONAL PERMEABILITY MODULATION, METHODS OF DETECTION AND USING DERIVATIVES THEREOF

摘要

In vitro methods and kits for modulating and studying mechanical movement of hepatic bile canaliculi lumen through activation or inhibition of the Rho-kinase molecular regulation pathway. In vitro methods and kits for modulating lumen opening and clearing using matrix metalloproteinases, as well as diagnostic methods based upon the same.