发明名称 |
METHODS AND PHARMACEUTICAL COMPOSITIONS (CTPS 1 INHIBITORS, E.G. NORLEUCINE) FOR INHIBITING T CELL PROLIFERATION IN A SUBJECT IN NEED THEREOF |
摘要 |
The present invention relates to methods and pharmaceutical compositions for inhibiting lymphocyte proliferationin a subject in need thereof. In particular, the invention relates to a CTP synthase 1 (CTPS1) inhibitor for use in a method for inhibiting lymphocyte proliferationin a subject in need thereof. The invention also relates to a method for screening a plurality of test substances useful for inhibiting lymphocyte proliferationin a subject in need thereof comprising the steps consisting of i) testing each of the test substances for its ability to inhibit CTPS1 activity or expression and ii) identifying the test substance which inhibits CTPS1 activity or expression thereby to identify a test substance useful for inhibiting lymphocyte proliferationin a subject in need thereof. |
申请公布号 |
EP2986287(A2) |
申请公布日期 |
2016.02.24 |
申请号 |
EP20140722572 |
申请日期 |
2014.04.17 |
申请人 |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM);FONDATION IMAGINE;UNIVERSITÉ PARIS DESCARTES;ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP);THE UNIVERSITY OF MANCHESTER |
发明人 |
LATOUR, SYLVAIN;FISCHER, ALAIN;MARTIN, EMMANUEL;ARKWRIGHT, PETER |
分类号 |
A61K31/198;A61K48/00;A61P37/00;A61P37/06 |
主分类号 |
A61K31/198 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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