USE OF A MONOPHOSPHATE ESTER OF A PHTHALEIN COMPOUND AS A SUBSTRATE FOR TARTRATE-RESISTANT ACID PHOSPHATASE B5 (TRAP 5B)

摘要

The present invention relates to the use of a monophosphate ester of a phthalein compound as a substrate for Tartrate-Resistant Acid Phosphotase (TRAP). The substrate is used in assays for obtaining a measure of the amount of TRAP 5b in a sample of a subject, as an indication of the rate of bone resorption and therefore the likelihood of conditions such as osteoporosis. Also provided are kits comprising a monophosphate ester of a phthalein compound and optionally an antibody which binds total TRAP and methods.