THERMOSENSITIVE MUTANTS OF INFLUENZA VIRUSES

摘要

The invention relates to thermosensitive mutants of influenza viruses, containing at least one mutation localised in a flexible region of a protein of said virus, such as especially the region of the sub-unit PA of the viral polymerase corresponding to the region 197-225 of the sub-unit PA of influenza A. These viruses can be especially used for preparing attenuated living vaccines.