IMMEDIATE RELEASE ORAL COMPOSITION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY DRUG AND PROTON PUMP INHIBITOR, AND METHOD FOR PREPARING THE SAME

摘要

The present invention relates to an immediate-release oral composition, which comprises: an inner capsule including a non-steroidal anti-inflammatory drug (NSAID) and a proton pump inhibitor (PPI); and an outer capsule including an alkaline buffer for surrounding the inner capsule. The composition of the present invention is composed of a dual capsule form for covering the outside with an alkaline buffer, thereby regulating a pH in a gastric environment and increasing the solubility of pH-dependent drug. The composition can be effectively used as an immediate-release composition which does not receive effects of the pH, by converting a crystalline form of drugs to an amorphous form, and improving the elution and the solubility of the drugs.