CHIMERIC NEWCASTLE DISEASE VIRUSES AND USES THEREOF

摘要

The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.