Compositions comprising decitabine and tetrahydrouridine and uses thereof

摘要

Embodiments of compositions and methods for the treatment of blood disorders and malignancies in a subject are described herein. In one embodiment, a composition for the treatment of a blood disorder or a malignancy in a subject comprises decitabine, tetrahydrouridine, and an excipient. In another embodiment, a method for the treatment of a blood disorder or a malignancy in a subject comprises the oral administration of a composition comprising decitabine and tetrahydrouridine. In some examples, the composition may be administered 1-3 times weekly.

主权项

1. A composition for oral administration comprising decitabine, tetrahydrouridine, and a pharmaceutically acceptable excipient, wherein said composition comprises about 1 to about 9.9 mg/m2 decitabine and about 300 to about 500 mg/m2 tetrahydrouridine.