Biocompatible particles and method for preparing same

摘要

Biocompatible particles, according to the present invention, have encapsulated nanoparticles comprising a liposome including a drug therein, and comprise a PEO-PPO-PEO copolymer which is associated on a surface of the liposome. The biocompatible particles, according to the present invention, can flexibly control a drug release rate regardless of the solubility unique to the drug due to increased stability in an aqueous solution, thereby exhibiting continuous drug release. Also, the present invention exists stably in a powder form, thereby providing convenience for storage and administration. Therefore, the biocompatible particles according to the present invention can be useful as a drug delivery carrier.

主权项

1. A method of preparing biocompatible particles, comprising:
preparing nanoparticles by mixing a drug with at least one polymer selected from the group consisting of a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) copolymer, poly(lactide-co-glycolide) (PLGA), poly caprolactone (PCL), poly(lactic acid) (PLA), poly(glycolic acid) (PGA), polyethylene glycol, and polysorbate; providing an aqueous solution comprising lecithin; mixing the nanoparticles with the aqueous solution comprising lecithin to form liposomes in which the nanoparticles are encapsulated; and mixing the nanoparticle-encapsulated liposome with an aqueous solution comprising a PEO-PPO-PEO copolymer and freeze-drying the resulting mixture.