| 主权项 |
1. A compound having Formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is —H, —C1-6alkyl, —OC1-6alkyl, —CH2F, —CH2OCH3, —SC1-6alkyl, —R13R14, R2 is —CH3, —CH2CH3 or —CH2CH2CH3; R3 is —CH2CH(CH3)2, —CH(CH3)2, —CH2C(CH3)2(OH), —CH(CH3)(CH2CH3) or —CH2CH(R7)(CH2CH3); R4 is —CH3 or —CH2OH; R5 is —R8(CH2)n(C═O)m—; R6 is —CH2CH3, —CH(CH3)(OH), —CH(CH3)2 or —CH2CH2CH3; R7 is OC1-5 alkyl; R8 is O, S, CH2O, CH2S or CH2; R9, R10, R11, and the N to which R9 and R10 are attached, together form a monocyclic or polycyclic non-aromatic heterocycle, wherein said heterocycle is optionally interrupted by a C═O, and the S and N atoms are optionally oxidized, and wherein said heterocycle is optionally substituted with halogen, nitro, cyano, —OC1-6 alkyl, —SC1-6 alkyl, —C1-6 alkyl, —C2-6 alkenyl, —C2-6 alkynyl, carboxylic acid, ester, ketone, aldehyde, amide, amine, sulfonamide, C3-8 cycloalkyl, hydroxyl or haloalkyl; R13 is O, S, CH2O, CH2S, CH2SO or CH2SO2; R14 is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, CH2CH2N(CH2CH3)2, CH2CH2NH(CH2CH3), heterocycle or aryl; n is 0, 1, 2, 3 or 4; m is 0 or 1; and p is 1; wherein R14 is optionally substituted with one or more groups independently selected from the group consisting of H, C1-6alkyl, halogen, hydroxyl, ester, sulfonamide, ketone, aldehyde, cycloalkyl, heterocycle, aryl, amine, heterocycle, amide and guanidinyl; and wherein “- - - - - -” is a single bond. |
